NEW DATA FROM O.S. ATTARYAN ET AL ILLUMINATE RESEARCH IN GENERAL CHEMISTRY
Science Letter
June 24, 2008
GENERAL CHEMISTRY;
According to recent research from Yerevan, Armenia, "A convenient
procedure has been developed for the synthesis of cis- and
trans-isomeric 1-(buta-1,3-dien-1-yl)-1H-pyrazoles by reaction of
the corresponding pyrazoles with P-methylacrolein diethyl acetal and
subsequent 1,4-cleavage of the nucleophilic substitution products."
"The behavior of the title compounds in Diels-Alder reactions with
maleic anhydride has been studied. According to the H-1 NMR data,
1-(buta-1,3-dien-1-yl)-1H-pyrazole is a mixture of cis and trans
isomers," wrote O.S. Attaryan and colleagues (see also General
Chemistry).
The researchers concluded: "Butadienylpyrazoles having methyl groups
in the pyrazole ring do not react with maleic anhydride."
Attaryan and colleagues published their study in Russian
Journal of General Chemistry (Synthesis and structure of
1-(Buta-1,3-dien-2-yl)pyrazoles and their behavior in Diels-Alder
reactions. Russian Journal of General Chemistry, 2008;78(3):457-460).
For additional information, contact O.S. Attaryan, National Academy
Science Armenia, Institute Organ Chemical, Ul Zakariya Sarkavaga 167A,
Yerevan 375091, Armenia.
Publisher contact information for the Russian Journal of General
Chemistry is: Maik Nauka, Interperiodica, Springer, 233 Spring St.,
New York, NY 10013-1578, USA.