Enzyme Research: Studies From National Academy Of Science Add New Fi

ENZYME RESEARCH: STUDIES FROM NATIONAL ACADEMY OF SCIENCE ADD NEW FINDINGS IN THE AREA OF ENZYME RESEARCH

Pharma Law Weekly
October 21, 2008

Scientists discuss in ‘Complex of dipeptidyl peptidase II with
adenosine deaminase’ new findings in enzyme research. According
to recent research from Yerevan, Armenia, "Dipeptidyl peptidase
II (DPPII) from bovine kidney cortex and lung was purified to the
electrophoretically homogeneous state. The molecular and catalytic
characteristics of the enzyme were determined."

"It was revealed that DPPII preparations possess adenosine deaminase
(ADA) activity at all purification steps. For the first time, the
ADA-binding ability of DPPII has been shown similar to the well-known
ADA-binding enzyme, DPPIV. The dissociation constant of the DPPII-ADA
complex was estimated using a resonant mirror biosensor (80 nM),
fluorescence polarization (60 nM), and differential spectroscopy
(36 nM) techniques," wrote S.G. Sharoyan and colleagues, National
Academy of Science (see also Enzyme Research).

The researchers concluded: "The data demonstrate that DPPII can form a
complex with ADA, but with one order of magnitude higher dissociation
constant than that of DPPIV (7.8 nM)."

Sharoyan and colleagues published their study in Biochemistry (Complex
of dipeptidyl peptidase II with adenosine deaminase. Biochemistry,
2008;73(8):943-9).

For additional information, contact S.G. Sharoyan, Buniatyan Institute
of Biochemistry, Armenian National Academy of Sciences, Yerevan,
Armenia.

Publisher contact information for the journal Biochemistry is: Maik
Nauka, Interperiodica, C, O Kluwer Academic-Plenum Publishers, 233
Spring St., New York, NY 10013-1578, USA.

From: Emil Lazarian | Ararat NewsPress

Emil Lazarian

“I should like to see any power of the world destroy this race, this small tribe of unimportant people, whose wars have all been fought and lost, whose structures have crumbled, literature is unread, music is unheard, and prayers are no more answered. Go ahead, destroy Armenia . See if you can do it. Send them into the desert without bread or water. Burn their homes and churches. Then see if they will not laugh, sing and pray again. For when two of them meet anywhere in the world, see if they will not create a New Armenia.” - WS